Platelet‐based coagulation: different populations, different functions

@article{Heemskerk2013PlateletbasedCD,
  title={Platelet‐based coagulation: different populations, different functions},
  author={Johan W. M. Heemskerk and Nadine J. A. Mattheij and Judith M.E.M. Cosemans},
  journal={Journal of Thrombosis and Haemostasis},
  year={2013},
  volume={11}
}
Summary.  Platelets in a thrombus interact with (anti)coagulation factors and support blood coagulation. In the concept of cell‐based control of coagulation, three different roles of platelets can be distinguished: control of thrombin generation, support of fibrin formation, and regulation of fibrin clot retraction. Here, we postulate that different populations of platelets with distinct surface properties are involved in these coagulant functions. Platelets with elevated Ca2+ and exposed… 
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