Platelet‐based coagulation: different populations, different functions

@article{Heemskerk2013PlateletbasedCD,
  title={Platelet‐based coagulation: different populations, different functions},
  author={Johan W. M. Heemskerk and Nadine J. A. Mattheij and Judith M.E.M. Cosemans},
  journal={Journal of Thrombosis and Haemostasis},
  year={2013},
  volume={11}
}
Summary.  Platelets in a thrombus interact with (anti)coagulation factors and support blood coagulation. In the concept of cell‐based control of coagulation, three different roles of platelets can be distinguished: control of thrombin generation, support of fibrin formation, and regulation of fibrin clot retraction. Here, we postulate that different populations of platelets with distinct surface properties are involved in these coagulant functions. Platelets with elevated Ca2+ and exposed… 
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262 Citations
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262 Citations

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Insights into platelet-based control of coagulation.
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Platelets and Coagulation
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This chapter describes the roles of platelets in detail, also focusing on the receptors and signaling pathways involved and on the distinct (anti)coagulant pathways.
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A microspot-based technique, which assessed platelet adhesion, platelet activation, thrombus structure and fibrin clot formation in real time using flowing whole blood, has revealed interaction mechanisms of platelet-primed key haemostatic pathways with alterations in patients with (anti)coagulation defects.
Integrating platelet and coagulation activation in fibrin clot formation
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Current concepts of platelet control of thrombin generation, fibrin formation and structure, and anticoagulation are discussed, to support the importance of the platelet‐coagulation interplay in the secondary prevention of cardiovascular disease.
Platelet-Mediated Modulation of Fibrinolysis.
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The diverse roles of platelets in fibrinolysis are discussed and the recent developments in the field are highlighted and the contribution of both the intracellular pool of modulators as well as the membrane surface in regulating these processes is highlighted.
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TLDR
This review summarizes the generation and important characteristics of procoagulant platelets, as well as their potential for preventing the adverse effects associated with current antiplatelet therapies.
Interplay between platelets and coagulation
[Molecular mechanisms of platelet activation].
  • C. Gachet
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    Bulletin de l'Academie nationale de medecine
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The major subpopulation of platelets involved in thrombus development form via regulated necrosis involving cyclophilin
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Elevated levels of “coated” platelets, defined as platelets with high levels of retained procoagulant proteins, have been demonstrated in patients with ischemic stroke and recurrent isChemic stroke, whereas low levels correlate with hemorrhagic complications of stroke.
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