Platelet‐Fibrinogen Interactions

@article{Bennett2001PlateletFibrinogenI,
  title={Platelet‐Fibrinogen Interactions},
  author={Joel S. Bennett},
  journal={Annals of the New York Academy of Sciences},
  year={2001},
  volume={936}
}
  • J. Bennett
  • Published 1 June 2001
  • Biology
  • Annals of the New York Academy of Sciences
Abstract: Binding of fibrinogen to GPIIb‐IIIa on agonist‐stimulated platelets results in platelet aggregation, presumably by crosslinking adjacent activated platelets. Although unactivated platelets express numerous copies of GPIIb‐IIIa on their surface, spontaneous, and potentially deleterious, platelet aggregation is prevented by tightly regulating the fibrinogen binding activity of GPIIb‐IIIa. Preliminary evidence suggests that it is the submembranous actin or actin‐associated proteins that… 
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