Plasticity of the motor cortex in Parkinson's disease patients on and off therapy.

@article{Bagnato2006PlasticityOT,
  title={Plasticity of the motor cortex in Parkinson's disease patients on and off therapy.},
  author={Sergio Bagnato and Rocco Agostino and Nicola Modugno and A. Quartarone and Alfredo Berardelli},
  journal={Movement disorders : official journal of the Movement Disorder Society},
  year={2006},
  volume={21 5},
  pages={639-45}
}
We used the paired associative stimulation (PAS) technique to investigate associative plasticity of the sensorimotor cortex in 16 Parkinson's disease (PD) patients off and on therapy and in 10 age-matched controls. After PAS, motor evoked potential (MEP) amplitudes increased more and the cortical silent period showed a reduced prolongation in patients off therapy than in controls. These changes lasted for at least 30 minutes. In addition, MEP amplitudes increased in a less focal manner in… CONTINUE READING