Plasticity of synapses in the rat neostriatum after unilateral lesion of the nigrostriatal dopaminergic pathway.

@article{Ingham1998PlasticityOS,
  title={Plasticity of synapses in the rat neostriatum after unilateral lesion of the nigrostriatal dopaminergic pathway.},
  author={Cali A. Ingham and Susan C. H. Hood and Peter Taggart and Gordon W. Arbuthnott},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1998},
  volume={18 12},
  pages={4732-43}
}
In the 6-hydroxydopamine model of Parkinson's disease in the rat, there is a significant reduction in the number of dendritic spines on the principal projection neurons in the neostriatum, presumably attributable to loss of the nigrostriatal dopamine input. These spines invariably receive input from terminals forming asymmetric synapses that originate mainly from the cortex. The object of the present study was to determine the fate of those terminals after the loss of dendritic spines. Unbiased… CONTINUE READING
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