Plasticity of reward neurocircuitry and the 'dark side' of drug addiction

@article{Koob2005PlasticityOR,
  title={Plasticity of reward neurocircuitry and the 'dark side' of drug addiction},
  author={George F. Koob and Michel le Moal},
  journal={Nature Neuroscience},
  year={2005},
  volume={8},
  pages={1442-1444}
}
Drug seeking is associated with activation of reward neural circuitry. Here we argue that drug addiction also involves a 'dark side'--a decrease in the function of normal reward-related neurocircuitry and persistent recruitment of anti-reward systems. Understanding the neuroplasticity of the dark side of this circuitry is the key to understanding vulnerability to addiction.