Plasticity of intrinsic neuronal excitability

  title={Plasticity of intrinsic neuronal excitability},
  author={Dominique Debanne and Yanis Inglebert and Micha{\"e}l Russier},
  journal={Current Opinion in Neurobiology},

Figures from this paper

The contribution of ion channels in input-output plasticity

Synergistic excitability plasticity in cerebellar functioning

The mechanisms underlying the induction of multiple types of plasticity in cerebellar circuit are introduced and an overview focusing on the plasticity of nonsynaptic intrinsic excitability is given.

Regulation of Hippocampal Gamma Oscillations by Modulation of Intrinsic Neuronal Excitability

The presented data suggest that voltage- and calcium-activated ion channels involved in intrinsic excitability strongly regulate the power of hippocampal gamma oscillations and that targeting these channels could represent a valuable pharmacological strategy against cognitive impairment.

Changes in cerebellar intrinsic neuronal excitability and synaptic plasticity result from eyeblink conditioning

  • B. Schreurs
  • Biology, Psychology
    Neurobiology of Learning and Memory
  • 2019

Calcium and Spike Timing-Dependent Plasticity

The importance of considering physiological levels of extracellular calcium concentration to study functional plasticity is discussed, which strongly depends on intracellular calcium influx for its induction.

Stability and learning in excitatory synapses by nonlinear inhibitory plasticity

It is demonstrated that the stable synaptic strengths realized by this novel inhibitory plasticity achieve a fixed excitatory/inhibitory set-point in agreement with experimental results.

Memory retention in pyramidal neurons: a unified model of energy-based homo and heterosynaptic plasticity with homeostasis.

The proposed plasticity model unifies homo- and heterosynaptic plasticity and can reproduce synaptic plasticity observed in multiple experiments, such as spike-timing-dependent plasticity, and cooperative plasticity with few and common parameters.

Kv1.1 contributes to a rapid homeostatic plasticity of intrinsic excitability in CA1 pyramidal neurons in vivo

Analysis of place cells’ out-of-field firing in mice navigating in virtual reality further revealed an experience-dependent reduction consistent with decreased excitability, and it is proposed that this mechanism could reduce memory interference.

Conventional measures of intrinsic excitability are poor estimators of neuronal activity under realistic synaptic inputs

A high-yield electrophysiological analysis of cultured mouse hippocampal neurons using both standard protocols and simulated synaptic inputs via dynamic clamp finds that under these conditions the neurons exhibit vastly different firing responses with surprisingly weak correlation between static and dynamic firing intensities.



Spike-Timing Dependent Plasticity Beyond Synapse – Pre- and Post-Synaptic Plasticity of Intrinsic Neuronal Excitability

The induction and expression mechanisms of the induced changes in excitability are described and the functional synergy between synaptic and non-synaptic plasticity and their spatial extent are discussed.

Long-term plasticity of intrinsic excitability: learning rules and mechanisms.

The role of synaptic activity seems to be a determinant in the induction of intrinsic plasticity in cortical, hippocampal, and cerebellar neurons, but the learning rules and the underlying mechanisms remain to be defined.

Plasticity in the intrinsic excitability of cortical pyramidal neurons

It is demonstrated that in response to changes in activity, cultured cortical pyramidal neurons regulate intrinsic excitability to promote stability in firing by selectively regulating voltage-dependent conductances.

Multiple forms of activity‐dependent intrinsic plasticity in layer V cortical neurones in vivo

It is demonstrated that neocortical pyramidal neurones can express in vivo a bidirectional use‐dependent intrinsic plasticity, modifying their sensitivity to weak inputs and/or the gain of their input–output function.

Long-Term Potentiation of Intrinsic Excitability at the Mossy Fiber–Granule Cell Synapse of Rat Cerebellum

High-frequency stimulation at the mossy fiber–granule cell relay of the cerebellum increased granule cell input resistance and decreased spike threshold, and potentiation of intrinsic excitability was induced by relatively weaker inputs than potentation of synaptic efficacy, whereas with stronger inputs the two aspect of potentiation combined to enhance EPSPs and spike generation.

The other side of the engram: experience-driven changes in neuronal intrinsic excitability

The evidence for persistent changes in intrinsic neuronal excitability — what the authors will call intrinsic plasticity — that is produced by training in behaving animals and by artificial patterns of activation in brain slices and neuronal cultures is considered.

Long-Term Depression of Intrinsic Excitability Accompanied by Synaptic Depression in Cerebellar Purkinje Cells

The results suggest that LTD-IE may have a synergistic effect with synaptic depression on the total net output of neurons by amplifying the modification of PF synaptic transmission and raise the prospect that this synaptic and intrinsic plasticity acts synergistically in PCs to modify neuronal activity in the same direction when learning occurs.

Bidirectional plasticity of excitatory postsynaptic potential (EPSP)-spike coupling in CA1 hippocampal pyramidal neurons

It is shown here that synaptic depression is associated with an N-methyl-d-aspartate receptor-dependent and long-lasting depression of E-S coupling and is synergic with glutamatergic long-term depression.