Plasticity of intrinsic neuronal excitability

@article{Debanne2019PlasticityOI,
  title={Plasticity of intrinsic neuronal excitability},
  author={Dominique Debanne and Yanis Inglebert and Michaël Russier},
  journal={Current Opinion in Neurobiology},
  year={2019},
  volume={54},
  pages={73-82}
}
Long-term synaptic modification is not the exclusive mode of memory storage, and persistent regulation of voltage-gated ion channels also participates in memory formation. Intrinsic plasticity is expressed in virtually all neuronal types including principal cells and interneurons. Activation of synaptic glutamate receptors initiates long-lasting changes in neuronal excitability at presynaptic and postsynaptic side. As synaptic plasticity, intrinsic plasticity is bi-directional and expresses a… Expand
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  • 2019
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References

SHOWING 1-10 OF 89 REFERENCES
Spike-Timing Dependent Plasticity Beyond Synapse – Pre- and Post-Synaptic Plasticity of Intrinsic Neuronal Excitability
TLDR
The induction and expression mechanisms of the induced changes in excitability are described and the functional synergy between synaptic and non-synaptic plasticity and their spatial extent are discussed. Expand
Bidirectional Modification of Presynaptic Neuronal Excitability Accompanying Spike Timing-Dependent Synaptic Plasticity
TLDR
It is reported that, associated with the induction of long-term depression in hippocampal cultures and in somatosensory cortical slices, there is also a persistent reduction in the excitability of the presynaptic neuron. Expand
Long-term plasticity of intrinsic excitability: learning rules and mechanisms.
TLDR
The role of synaptic activity seems to be a determinant in the induction of intrinsic plasticity in cortical, hippocampal, and cerebellar neurons, but the learning rules and the underlying mechanisms remain to be defined. Expand
Plasticity in the intrinsic excitability of cortical pyramidal neurons
TLDR
It is demonstrated that in response to changes in activity, cultured cortical pyramidal neurons regulate intrinsic excitability to promote stability in firing by selectively regulating voltage-dependent conductances. Expand
Long-Lasting Increases in Intrinsic Excitability Triggered by Inhibition
TLDR
Firing rate potentiation is a novel form of cellular plasticity that could contribute to motor learning in the vestibulo-ocular reflex and may serve as a complementary mechanism to synaptic plasticity. Expand
Multiple forms of activity‐dependent intrinsic plasticity in layer V cortical neurones in vivo
TLDR
It is demonstrated that neocortical pyramidal neurones can express in vivo a bidirectional use‐dependent intrinsic plasticity, modifying their sensitivity to weak inputs and/or the gain of their input–output function. Expand
Long-Term Potentiation of Intrinsic Excitability at the Mossy Fiber–Granule Cell Synapse of Rat Cerebellum
TLDR
High-frequency stimulation at the mossy fiber–granule cell relay of the cerebellum increased granule cell input resistance and decreased spike threshold, and potentiation of intrinsic excitability was induced by relatively weaker inputs than potentation of synaptic efficacy, whereas with stronger inputs the two aspect of potentiation combined to enhance EPSPs and spike generation. Expand
The other side of the engram: experience-driven changes in neuronal intrinsic excitability
TLDR
The evidence for persistent changes in intrinsic neuronal excitability — what the authors will call intrinsic plasticity — that is produced by training in behaving animals and by artificial patterns of activation in brain slices and neuronal cultures is considered. Expand
Long-Term Depression of Intrinsic Excitability Accompanied by Synaptic Depression in Cerebellar Purkinje Cells
TLDR
The results suggest that LTD-IE may have a synergistic effect with synaptic depression on the total net output of neurons by amplifying the modification of PF synaptic transmission and raise the prospect that this synaptic and intrinsic plasticity acts synergistically in PCs to modify neuronal activity in the same direction when learning occurs. Expand
Bidirectional plasticity of excitatory postsynaptic potential (EPSP)-spike coupling in CA1 hippocampal pyramidal neurons
TLDR
It is shown here that synaptic depression is associated with an N-methyl-d-aspartate receptor-dependent and long-lasting depression of E-S coupling and is synergic with glutamatergic long-term depression. Expand
...
1
2
3
4
5
...