Plasticity of hydrogen bond networks regulates mechanochemistry of cell adhesion complexes

  title={Plasticity of hydrogen bond networks regulates mechanochemistry of cell adhesion complexes},
  author={Shaon Chakrabarti and Michael Hinczewski and D. Thirumalai},
  journal={Proceedings of the National Academy of Sciences},
  pages={9048 - 9053}
Significance Selectins and integrins are receptor proteins on cell surfaces responsible for adhesion to extracellular biomolecules, a critical component of physiological processes like white blood cell localization at sites of inflammation. The bonds which the receptors form with their targets are regulated by mechanical forces (for example due to blood flow). The bond lifetimes before rupture increase with force before decreasing. Based on crystal structures of selectin and integrin, we… 

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    Proceedings of the National Academy of Sciences
  • 2009
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