Plasticity of hippocampus following perinatal asphyxia: effects on postnatal apoptosis and neurogenesis.

@article{Morales2008PlasticityOH,
  title={Plasticity of hippocampus following perinatal asphyxia: effects on postnatal apoptosis and neurogenesis.},
  author={Paola Morales and Jenny L Fiedler and Sergio Andr{\'e}s and Cecilia Berr{\'i}os and P. Huaiquin and Diego A. Bustamante and Sergio C{\'a}rdenas and Eduardo Parra and Mario Herrera-Marschitz},
  journal={Journal of neuroscience research},
  year={2008},
  volume={86 12},
  pages={2650-62}
}
Asphyxia during delivery produces long-term deficits in brain development, including hippocampus. We investigated hippocampal plasticity after perinatal asphyxia, measuring postnatal apoptosis and neurogenesis. Asphyxia was performed by immersing rat fetuses with uterine horns removed from ready-to-deliver rats into a water bath for 20 min. Caesarean-delivered pups were used as controls. The animals were euthanized 1 week or 1 month after birth. Apoptotic nuclear morphology and DNA breaks were… CONTINUE READING

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