Plasticity of brain alpha-adrenoceptors during the development of diet-induced obesity in the rat.

@article{Levin1994PlasticityOB,
  title={Plasticity of brain alpha-adrenoceptors during the development of diet-induced obesity in the rat.},
  author={Barry E. Levin and Michael W. Hamm},
  journal={Obesity research},
  year={1994},
  volume={2 3},
  pages={230-8}
}
Male Sprague-Dawley rats, which are prone to develop diet-induced obesity (DIO) on a high energy (HE) diet can be separated from rats which are diet-resistant (DR) by several prospective tests. Using such tests, chow-fed DRl-prone rats have higher binding of 3H paraminoclonidine (PAC) to brain alpha2-adrenoceptors than do DIO-prone rats. These differences disappear after 3 months on a HE diet. To study the predictive value of these tests and possible associated changes in presynaptic membrane… CONTINUE READING