Plasticity of Polarization: Changing Dendrites into Axons in Neurons Integrated in Neuronal Circuits

Abstract

Developing neurons can change axonal and dendritic fate upon axonal lesion, but it is unclear whether neurons retain such plasticity when they are synaptically interconnected. To address whether polarity is reversible in mature neurons, we cut the axon of GFP-labeled hippocampal neurons in dissociated and organotypic cultures and found that a new axon arose… (More)
DOI: 10.1016/j.cub.2008.06.026

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