Plasticity of Cultured Mesenchymal Stem Cells: Switch from Nestin‐Positive to Excitable Neuron‐Like Phenotype

@article{WisletGendebien2005PlasticityOC,
  title={Plasticity of Cultured Mesenchymal Stem Cells: Switch from Nestin‐Positive to Excitable Neuron‐Like Phenotype},
  author={Sabine Wislet-Gendebien and Gr{\'e}gory Hans and Pierre Leprince and Jean-Michel Rigo and Gustave Moonen and Bernard Rogister},
  journal={STEM CELLS},
  year={2005},
  volume={23}
}
Bone marrow mesenchymal stem cells (MSCs) can differentiate into several types of mesenchymal cells, including osteocytes, chondrocytes, and adipocytes, but, under appropriate experimental conditions, can also differentiate into nonmesenchymal cells—for instance, neural cells. These observations have raised interest in the possible use of MSCs in cell therapy strategies for various neurological disorders. In the study reported here, we addressed the question of in vitro differentiation of MSCs… 

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