Plasticity in the intrinsic excitability of cortical pyramidal neurons

@article{Desai1999PlasticityIT,
  title={Plasticity in the intrinsic excitability of cortical pyramidal neurons},
  author={Niraj S. Desai and Lana C. Rutherford and Gina G. Turrigiano},
  journal={Nature Neuroscience},
  year={1999},
  volume={2},
  pages={515-520}
}
During learning and development, the level of synaptic input received by cortical neurons may change dramatically. Given a limited range of possible firing rates, how do neurons maintain responsiveness to both small and large synaptic inputs? We demonstrate that in response to changes in activity, cultured cortical pyramidal neurons regulate intrinsic excitability to promote stability in firing. Depriving pyramidal neurons of activity for two days increased sensitivity to current injection by… CONTINUE READING
Highly Influential
This paper has highly influenced 57 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 379 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 47 references

Similar Papers

Loading similar papers…