Plasticity in the intrinsic excitability of cortical pyramidal neurons

  title={Plasticity in the intrinsic excitability of cortical pyramidal neurons},
  author={Niraj S. Desai and Lana C. Rutherford and Gina G. Turrigiano},
  journal={Nature Neuroscience},
During learning and development, the level of synaptic input received by cortical neurons may change dramatically. Given a limited range of possible firing rates, how do neurons maintain responsiveness to both small and large synaptic inputs? We demonstrate that in response to changes in activity, cultured cortical pyramidal neurons regulate intrinsic excitability to promote stability in firing. Depriving pyramidal neurons of activity for two days increased sensitivity to current injection by… CONTINUE READING
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