Plasticity in the adult rat pancreas: transdifferentiation of exocrine to hepatocyte-like cells in primary culture.

@article{Lardon2004PlasticityIT,
  title={Plasticity in the adult rat pancreas: transdifferentiation of exocrine to hepatocyte-like cells in primary culture.},
  author={Jessy Lardon and Saskia De Breuck and Ilse Rooman and Leentje van Lommel and Mogens Kruh\offer and Torben Falck Orntoft and Frans Schuit and Luc Bouwens},
  journal={Hepatology},
  year={2004},
  volume={39 6},
  pages={1499-507}
}
Under certain experimental conditions, hepatocytes can arise in the pancreas. It has been suggested that the pancreas retains a source of hepatocyte progenitor cells. However, such cells have not been yet identified in the adult pancreas. We describe here the transdifferentiation of primary rat pancreatic exocrine cells into hepatocyte-like cells during 5 days of tissue culture in the presence of dexamethasone (DX). Using reverse-transcription polymerase chain reaction and immunocytochemistry… CONTINUE READING

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