Plasticity in serotonin control mechanisms in the gut.

  title={Plasticity in serotonin control mechanisms in the gut.},
  author={Michael David Gershon},
  journal={Current opinion in pharmacology},
  volume={3 6},
5-hydroxytryptamine (5-HT or serotonin) is a charged molecule and must be transported across biological membranes. Enzymes that catabolize 5-HT are all intracellular; therefore, 5-HT inactivation requires a high affinity transporter, known as serotonin transporter (SERT or 5-HTT). In the central and enteric nervous systems, SERT is located in serotonergic neurons; however, these neurons are not present in the gastrointestinal mucosa, where 5-HT initiates peristaltic and secretory reflexes… CONTINUE READING


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