Plasticity-dependent, full detonation at hippocampal mossy fiber–CA3 pyramidal neuron synapses

  title={Plasticity-dependent, full detonation at hippocampal mossy fiber–CA3 pyramidal neuron synapses},
  author={Nicholas P. Vyleta and Carolina Borges-Merjane and P{\'e}ter J{\'o}n{\'a}s},
Mossy fiber synapses on CA3 pyramidal cells are 'conditional detonators' that reliably discharge postsynaptic targets. The 'conditional' nature implies that burst activity in dentate gyrus granule cells is required for detonation. Whether single unitary excitatory postsynaptic potentials (EPSPs) trigger spikes in CA3 neurons remains unknown. Mossy fiber synapses exhibit both pronounced short-term facilitation and uniquely large post-tetanic potentiation (PTP). We tested whether PTP could… CONTINUE READING
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