Plasticity-dependent, full detonation at hippocampal mossy fiber–CA3 pyramidal neuron synapses

@inproceedings{Vyleta2016PlasticitydependentFD,
  title={Plasticity-dependent, full detonation at hippocampal mossy fiber–CA3 pyramidal neuron synapses},
  author={Nicholas P. Vyleta and Carolina Borges-Merjane and P{\'e}ter J{\'o}n{\'a}s},
  booktitle={eLife},
  year={2016}
}
Mossy fiber synapses on CA3 pyramidal cells are 'conditional detonators' that reliably discharge postsynaptic targets. The 'conditional' nature implies that burst activity in dentate gyrus granule cells is required for detonation. Whether single unitary excitatory postsynaptic potentials (EPSPs) trigger spikes in CA3 neurons remains unknown. Mossy fiber synapses exhibit both pronounced short-term facilitation and uniquely large post-tetanic potentiation (PTP). We tested whether PTP could… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 3 times. VIEW TWEETS

References

Publications referenced by this paper.
Showing 1-10 of 63 references

Dendritic computation.

Annual review of neuroscience • 2005
View 4 Excerpts
Highly Influenced

Distinct short-term plasticity at two excitatory synapses in the hippocampus.

Proceedings of the National Academy of Sciences of the United States of America • 1996
View 6 Excerpts
Highly Influenced

Control of CA3 output by feedforward inhibition despite developmental changes in the excitation-inhibition balance.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2010
View 3 Excerpts
Highly Influenced

Structural determinants of transmission at large hippocampal mossy fiber synapses

A Rollenhagen, K Sätzler, +3 authors JH. Lübke
Journal of Neuroscience 27:10434–10444 • 2007
View 4 Excerpts
Highly Influenced

vivo. Nature Neuroscience 5:790–795

P Jonas, G Major, B. Sakmann
1993
View 2 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…