Plasticity and redundancy in the integration of adult born neurons in the hippocampus

  title={Plasticity and redundancy in the integration of adult born neurons in the hippocampus},
  author={Thiago F. A. França},
  journal={Neurobiology of Learning and Memory},

Rewiring of Memory Circuits: Connecting Adult Newborn Neurons With the Help of Microglia

This work focuses on microglia, the resident immune cells of the CNS, which modulate the production of new neurons in the adult hippocampus and are also well suited to participate in their circuit integration.

SREBP-1c Deficiency Affects Hippocampal Micromorphometry and Hippocampus-Dependent Memory Ability in Mice

This study suggests that the contributions of SREBP-1c to the structural plasticity of the mouse hippocampus may have underlain the behavioral alterations of schizophrenia-like behaviors in mice.

Heat shock protein 70 increases cell proliferation, neuroblast differentiation, and the phosphorylation of CREB in the hippocampus

Results suggest that Tat-HSP70 promoted hippocampal functions by increasing the pCREB in the hippocampus through penetration into the blood–brain barrier and neuronal plasma membrane.

How the Hippocampus Represents Memories: Making Sense of Memory Allocation Studies

An alternative hypothesis is argued that neurons in high‐order brain regions can be tuned to multiple dimensions, forming complex, abstract representations, and this allows those neurons to show some flexibility in their responses while still representing relatively fixed sets of stimuli.



Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation

It is shown that inducible genetic expansion of the population of adult-born neurons through enhancing their survival improves performance in a specific cognitive task in which two similar contexts need to be distinguished, which is indicative of enhanced pattern separation.

Critical periods regulating the circuit integration of adult-born hippocampal neurons

Some of the most recent insights into this almost unique form of plasticity in the adult brain are reviewed, focusing on those critical periods marked by pronounced changes in structure and function of the new granule neurons and discuss how the activity of putative synaptic partners may contribute to shape the circuit module in which new neurons become finally integrated.

Neurogenesis paradoxically decreases both pattern separation and memory interference

A novel computational model of the dentate gyrus is proposed that incorporates the developmental trajectory of the adult-born dentate granule cells, including changes in synaptic plasticity, connectivity, excitability and lateral inhibition, using a modified version of the Restricted Boltzmann machine.

Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus.

This review focuses on how developing neurons remodel the adult dentate gyrus and discusses key aspects that illustrate the potential of neurogenesis as a mechanism for circuit plasticity and function.

Juvenile neurogenesis makes essential contributions to adult brain structure and plays a sex-dependent role in fear memories

Postnatal neurogenesis (PNN) contributes neurons to olfactory bulb (OB) and dentate gyrus (DG) throughout juvenile development, but the quantitative amount, temporal dynamics and functional roles of

Activation of local inhibitory circuits in the dentate gyrus by adult‐born neurons

Optogenetic stimulation of a cohort of young adult‐born GCs revealed that these cells activate local GABAergic interneurons to evoke strong inhibitory input to mature GCs, and demonstrated that elevating activity in adult‐ born GCs in awake behaving animals reduced the overall number of matureGCs activated by exploration.

Potential role for adult neurogenesis in the encoding of time in new memories

The possibility that one cognitive impact of this gradually changing population of young granule cells on hippocampal memory formation is the formation of the temporal clusters of long-term episodic memories seen in some human psychological studies is discussed.