Plasmonic nanoparticle dimers for optical sensing of DNA in complex media.

  title={Plasmonic nanoparticle dimers for optical sensing of DNA in complex media.},
  author={Jennifer I L Chen and Yeechi Chen and David S. Ginger},
  journal={Journal of the American Chemical Society},
  volume={132 28},
We introduce a new sensing modality based on the actuation of discrete gold nanoparticle dimers. Binding of the target DNA leads to a geometrical extension of the dimer, thereby yielding a spectral blue shift in the hybridized plasmon mode as detected by single nanostructure scattering spectroscopy. The magnitude and opposite direction of this shift enabled us to spectroscopically distinguish the target from nonspecific binding and to detect the target in complex media like serum. 
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