Plasmon-enhanced stimulated Raman scattering microscopy with single-molecule detection sensitivity

@article{Zong2019PlasmonenhancedSR,
  title={Plasmon-enhanced stimulated Raman scattering microscopy with single-molecule detection sensitivity},
  author={Cheng Zong and Ranjith Premasiri and Haonan Lin and Yimin Huang and Chi Zhang and Chen Yang and Bin Ren and Lawrence D. Ziegler and Ji‐Xin Cheng},
  journal={Nature Communications},
  year={2019},
  volume={10}
}
Stimulated Raman scattering (SRS) microscopy allows for high-speed label-free chemical imaging of biomedical systems. The imaging sensitivity of SRS microscopy is limited to ~10 mM for endogenous biomolecules. Electronic pre-resonant SRS allows detection of sub-micromolar chromophores. However, label-free SRS detection of single biomolecules having extremely small Raman cross-sections (~10−30 cm2 sr−1) remains unreachable. Here, we demonstrate plasmon-enhanced stimulated Raman scattering (PESRS… 

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