Plasmodium vivax malaria in Southeast Iran in 1999-2001: establishing the response to chloroquine in vitro and in vivo.

@article{Hamedi2002PlasmodiumVM,
  title={Plasmodium vivax malaria in Southeast Iran in 1999-2001: establishing the response to chloroquine in vitro and in vivo.},
  author={Yaghoob Hamedi and Mehdi Nateghpour and Peerapan Tan-Ariya and Montip Tiensuwan and Udomsak Silachamroon and Sornchai Looareesuwan},
  journal={The Southeast Asian journal of tropical medicine and public health},
  year={2002},
  volume={33 3},
  pages={512-8}
}
Chloroquine-resistant Plasmodium vivax is emerging in Oceania, Asia and Latin America. The drug sensitivity of P. vivax to chloroquine both in vivo and in vitro in the southern part of Iran was assessed; chloroquine-resistant Plasmodium falciparum has already been documented in this area. The in vitro sensitivity of 39 P. vivax isolates was assessed: the mean IC50 and IC90 were 189 ng/ml and 698 ng/ml blood respectively; for in vivo testing, all 39 vivax malaria patients were treated with a… CONTINUE READING

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