Plasmodium vivax and the importance of the subtelomeric multigene vir superfamily.

  title={Plasmodium vivax and the importance of the subtelomeric multigene vir superfamily.},
  author={Carmen Fern{\'a}ndez-Becerra and M{\'a}rcio Massao Yamamoto and Ricardo Z. N. V{\^e}ncio and Marcus Vin{\'i}cius Guimar{\~a}es de Lacerda and Anna Rosanas-Urgell and Hernando A Del Portillo},
  journal={Trends in parasitology},
  volume={25 1},
Plasmodium vivax is responsible for more than 100 million clinical cases yearly. Unlike P. falciparum, in which infected red blood cells cytoadhere via variant proteins, avoiding passage through the spleen, P.-vivax-infected reticulocytes seem not to cytoadhere. However, a variant subtelomeric multigene vir family has been identified in P. vivax. Thus, questions remain about how P. vivax circulates through the spleen and the role of Vir proteins. In this review, the importance of the vir… CONTINUE READING

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