Plasmodium subtilisin-like protease 1 (SUB1): Insights into the active-site structure, specificity and function of a pan-malaria drug target

@article{WithersMartinez2012PlasmodiumSP,
  title={Plasmodium subtilisin-like protease 1 (SUB1): Insights into the active-site structure, specificity and function of a pan-malaria drug target},
  author={C. Withers-Martinez and C. Suarez and Simone Fulle and S. Kher and Maria Penzo and Jean-Paul Ebejer and Kostas Koussis and F. Hackett and A. Jirgensons and P. Finn and M. Blackman},
  journal={International Journal for Parasitology},
  year={2012},
  volume={42},
  pages={597 - 612}
}
  • C. Withers-Martinez, C. Suarez, +8 authors M. Blackman
  • Published 2012
  • Chemistry, Biology, Medicine
  • International Journal for Parasitology
  • Release of the malaria merozoite from its host erythrocyte (egress) and invasion of a fresh cell are crucial steps in the life cycle of the malaria pathogen. Subtilisin-like protease 1 (SUB1) is a parasite serine protease implicated in both processes. In the most dangerous human malarial species, Plasmodium falciparum, SUB1 has previously been shown to have several parasite-derived substrates, proteolytic cleavage of which is important both for egress and maturation of the merozoite surface to… CONTINUE READING
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