• DOI:10.1016/j.ijpara.2012.04.005
Corpus ID: 34527491

Plasmodium subtilisin-like protease 1 (SUB1): Insights into the active-site structure, specificity and function of a pan-malaria drug target

@article{WithersMartinez2012PlasmodiumSP,
  title={Plasmodium subtilisin-like protease 1 (SUB1): Insights into the active-site structure, specificity and function of a pan-malaria drug target},
  author={C. Withers-Martinez and C. Suarez and Simone Fulle and S. Kher and Maria Penzo and Jean-Paul Ebejer and Kostas Koussis and F. Hackett and A. Jirgensons and P. Finn and M. Blackman},
  journal={International Journal for Parasitology},
  year={2012},
  volume={42},
  pages={597 - 612}
}

C. Withers-Martinez, C. Suarez, +8 authors M. Blackman

Published 2012

Chemistry, Biology, Medicine

International Journal for Parasitology

Release of the malaria merozoite from its host erythrocyte (egress) and invasion of a fresh cell are crucial steps in the life cycle of the malaria pathogen. Subtilisin-like protease 1 (SUB1) is a parasite serine protease implicated in both processes. In the most dangerous human malarial species, Plasmodium falciparum, SUB1 has previously been shown to have several parasite-derived substrates, proteolytic cleavage of which is important both for egress and maturation of the merozoite surface to… CONTINUE READING

View on PubMed

doi.org

Save to Library

Create Alert

Cite

Launch Research Feed