Plasmodium knowlesi provides a rapid in vitro and in vivo transfection system that enables double-crossover gene knockout studies.

@article{Kocken2002PlasmodiumKP,
  title={Plasmodium knowlesi provides a rapid in vitro and in vivo transfection system that enables double-crossover gene knockout studies.},
  author={Clemens H. M. Kocken and Hastings Suba Ozwara and Annemarie van der Wel and Annette L Beetsma and Jason M. Mwenda and Alan W. Thomas},
  journal={Infection and immunity},
  year={2002},
  volume={70 2},
  pages={655-60}
}
Transfection technology for malaria parasites provides a valuable tool for analyzing gene function and correlating genotype with phenotype. Transfection models are even more valuable when appropriate animal models are available in addition to complete in vitro systems to be able to fully analyze parasite-host interactions. Here we describe the development of such a model by using the nonhuman primate malaria Plasmodium knowlesi. Blood-stage parasites were adapted to long-term in vitro culture… CONTINUE READING
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