Plasmodium falciparum variant surface antigen expression varies between isolates causing severe and nonsevere malaria and is modified by acquired immunity.

@article{Nielsen2002PlasmodiumFV,
  title={Plasmodium falciparum variant surface antigen expression varies between isolates causing severe and nonsevere malaria and is modified by acquired immunity.},
  author={Morten Agertoug Nielsen and Trine Staalsoe and Joergen A. L. Kurtzhals and Bamenla Quarm Goka and Daniel Dodoo and Michael Alifrangis and Thor G. Theander and Bartholomew Dicky Akanmori and Lars Hviid},
  journal={Journal of immunology},
  year={2002},
  volume={168 7},
  pages={
          3444-50
        }
}
In areas of endemic parasite transmission, protective immunity to Plasmodium falciparum malaria is acquired over several years with numerous disease episodes. Acquisition of Abs to parasite-encoded variant surface Ags (VSA) on the infected erythrocyte membrane is important in the development of immunity, as disease-causing parasites appear to be those not controlled by preexisting VSA-specific Abs. In this work we report that VSA expressed by parasites from young Ghanaian children with P… CONTINUE READING

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