Plasmodium falciparum transmission blocking monoclonal antibodies recognize monovalently expressed epitopes.

@article{Vermeulen1985PlasmodiumFT,
  title={Plasmodium falciparum transmission blocking monoclonal antibodies recognize monovalently expressed epitopes.},
  author={Arno N Vermeulen and Will F. G. Roeffen and J. B. J. Henderik and Thivi Ponnudurai and Pieter J. A. Beckers and Joseph H. E. T H Meuwissen},
  journal={Developments in biological standardization},
  year={1985},
  volume={62},
  pages={91-7}
}
Target proteins of transmission blocking monoclonal antibodies (MoAbs) are present on the surface of Plasmodium falciparum macrogametes with Mr of 48,000 and 45,000 and on the surface of developing ookinetes with Mr of 25,000. Other MoAbs directed against the same proteins were not able to reduce the number of oocysts in mosquitoes. A combination of a blocking MoAb with a non-blocking one potentiated the transmission blocking effect. This implies that at least two different epitopes are present… CONTINUE READING

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