Plasmodium falciparum responds to amino acid starvation by entering into a hibernatory state.

@article{Babbitt2012PlasmodiumFR,
  title={Plasmodium falciparum responds to amino acid starvation by entering into a hibernatory state.},
  author={Shalon E Babbitt and Lindsey M. Altenhofen and Simon A. Cobbold and Eva S Istvan and Clare Fennell and Christian Doerig and Manuel Llin{\'a}s and Daniel E Goldberg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 47},
  pages={E3278-87}
}
The human malaria parasite Plasmodium falciparum is auxotrophic for most amino acids. Its amino acid needs are met largely through the degradation of host erythrocyte hemoglobin; however the parasite must acquire isoleucine exogenously, because this amino acid is not present in adult human hemoglobin. We report that when isoleucine is withdrawn from the culture medium of intraerythrocytic P. falciparum, the parasite slows its metabolism and progresses through its developmental cycle at a… CONTINUE READING

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