Plasmodium falciparum intercellular adhesion molecule-1-based cytoadherence-related signaling in human endothelial cells.

Abstract

BACKGROUND Cytoadherence of Plasmodium falciparum-infected erythrocytes to host endothelium has been associated with pathology in severe malaria, but, despite extensive information on the primary processes involved in the adhesive interactions, the mechanisms underlying disease are poorly understood. METHODS We compared parasite lines varying in their… (More)

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