Plasmodium falciparum expresses a multidrug resistance-associated protein.

  title={Plasmodium falciparum expresses a multidrug resistance-associated protein.},
  author={Antonios Klokouzas and Teresa Tiffert and Donelly Andrew van Schalkwyk and C Wu and Hendrik W van Veen and Margery A. Barrand and Stephen Hladky},
  journal={Biochemical and biophysical research communications},
  volume={321 1},
Plasmodium falciparum proteins that efflux toxic metabolic products such as oxidised glutathione (GSSG) are possible targets for anti-malarial drug development. Proteins capable of transporting GSSG and glutathione conjugates include the multidrug resistance-associated transporters (MRPs). A gene, PFA0590w, encoding a MRP homologue, has been identified in P. falciparum. Here we show the presence of full-length mRNA (5.5 kb) of this PfMRP in trophozoites by RT-PCR and Northern blotting. A… CONTINUE READING
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