Plasmodium falciparum antigen-induced human immunodeficiency virus type 1 replication is mediated through induction of tumor necrosis factor-alpha.

@article{Xiao1998PlasmodiumFA,
  title={Plasmodium falciparum antigen-induced human immunodeficiency virus type 1 replication is mediated through induction of tumor necrosis factor-alpha.},
  author={Lihua Xiao and Sherry Michele Owen and Donna L. Rudolph and Renu B. Lal and A. Ashirbadi Lal},
  journal={The Journal of infectious diseases},
  year={1998},
  volume={177 2},
  pages={
          437-45
        }
}
Because malaria-stimulated cytokine production may have deleterious effects on human immunodeficiency virus type 1 (HIV-1) replication, the effects of Plasmodium falciparum antigens on HIV-1 replication were studied. Stimulation with malarial antigens significantly enhanced HIV-1 replication of HIV-1LAV and primary HIV-1 isolates (subtype A) in CD8-depleted peripheral blood mononuclear cells from naive donors. The malarial antigen-induced activation of HIV-1 was due to cellular activation as… CONTINUE READING
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