Plasmodium falciparum Na+/H+ exchanger 1 transporter is involved in reduced susceptibility to quinine.

@article{Henry2009PlasmodiumFN,
  title={Plasmodium falciparum Na+/H+ exchanger 1 transporter is involved in reduced susceptibility to quinine.},
  author={Maud Henry and S{\'e}bastien Briolant and Agn{\`e}s Zettor and St{\'e}phane Pelleau and Me{\"i}li C. Baragatti and Eric Baret and Joel Mosnier and R{\'e}my Amalvict and Thierry Fusai and Christophe Rogier and Bruno Pradines},
  journal={Antimicrobial agents and chemotherapy},
  year={2009},
  volume={53 5},
  pages={1926-30}
}
Polymorphisms in the Plasmodium falciparum crt (Pfcrt), Pfmdr1, and Pfmrp genes were not significantly associated with quinine (QN) 50% inhibitory concentrations (IC(50)s) in 23 strains of Plasmodium falciparum. An increased number of DNNND repeats in Pfnhe-1 microsatellite ms4760 was associated with an increased IC(50) of QN (P = 0.0007). Strains with only one DNNND repeat were more susceptible to QN (mean IC(50) of 154 nM). Strains with two DNNND repeats had intermediate susceptibility to QN… CONTINUE READING

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