Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL), a Resistance Mechanism for Two Distinct Compound Classes

@inproceedings{Magistrado2016PlasmodiumFC,
  title={Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL), a Resistance Mechanism for
Two Distinct Compound Classes},
  author={Pamela A. Magistrado and Victoria C. Corey and Amanda K Lukens and Greg LaMonte and Erika Sasaki and Stephan Meister and Melanie Wree and Elizabeth A. Winzeler and Dyann F Wirth},
  booktitle={ACS infectious diseases},
  year={2016}
}
MMV007564 is a novel antimalarial benzimidazolyl piperidine chemotype identified in cellular screens. To identify the genetic determinant of MMV007564 resistance, parasites were cultured in the presence of the compound to generate resistant lines. Whole genome sequencing revealed distinct mutations in the gene named Plasmodium falciparum cyclic amine resistance locus (pfcarl), encoding a conserved protein of unknown function. Mutations in pfcarl are strongly associated with resistance to a… CONTINUE READING