Plasmodium falciparum: role of absolute stereochemistry in the antimalarial activity of synthetic amino alcohol antimalarial agents.

@article{Karle1993PlasmodiumFR,
  title={Plasmodium falciparum: role of absolute stereochemistry in the antimalarial activity of synthetic amino alcohol antimalarial agents.},
  author={Jean M. Karle and Rosa E Olmeda and Lucia Gerena and Wilbur K. Milhous},
  journal={Experimental parasitology},
  year={1993},
  volume={76 4},
  pages={345-51}
}
The (+)-isomers of mefloquine and its threo analog are 1.69 to 1.95 times more active than the (-)-isomers against chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum in vitro. This large a differential between the activity of (+)- and (-)-isomers was not observed for other synthetic amino alcohol antimalarial agents containing a piperidine ring. The enantiomers of amino alcohol antimalarial agents in which the amine is part of an acyclic group, such as in halofantrine… CONTINUE READING

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