Plasmodium falciparum: in vitro growth inhibition by febrile temperatures

  title={Plasmodium falciparum: in vitro growth inhibition by febrile temperatures},
  author={Huiping Long and Bertrand Lell and Klaus Dietz and Peter Gottfried Kremsner},
  journal={Parasitology Research},
Febrile episodes are the hallmark of malarial infection. We determined the inhibitory effect of febrile temperatures on the in vitro growth of Plasmodium falciparum. Parasites were cultured at various temperatures between 37 °C and 40 °C for 4 days. A logistic decrease in parasitaemia as a function of temperature was observed for continuous cultures. Incubation of synchronized cultures for different lengths of time during the parasite cycle showed a strong increase of growth inhibition with the… CONTINUE READING