Plasmodium falciparum: immunogenicity of circumsporozoite protein constructs produced in Escherichia coli.

@article{Wirtz1987PlasmodiumFI,
  title={Plasmodium falciparum: immunogenicity of circumsporozoite protein constructs produced in Escherichia coli.},
  author={Robert Andrew Wirtz and William Ripley Ballou and Imogene Schneider and Louis Chedid and M. J. Gross and J. F. Young and Michael R Hollingdale and Carter L. Diggs and Wayne Hockmeyer},
  journal={Experimental parasitology},
  year={1987},
  volume={63 2},
  pages={166-72}
}
The immunogenicity of Plasmodium falciparum recombinant circumsporozoite protein constructs R16tet32, R32tet32, and R48tet32 in mice was examined by measuring antibody responses by enzyme linked immunosorbent assay, immunofluorescence, circumsporozoite precipitation, and inhibition of sporozoite invasion. All three constructs were found to be immunogenic when administered alone, but antibody responses were greater for the larger constructs, R32tet32 and R48tet32. Increased dose, boosting, and… CONTINUE READING
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