Plasmodium falciparum: cloning by single-erythrocyte micromanipulation and heterogeneity in vitro.


Natural isolates of Plasmodium falciparum represent a genetically heterogeneous population of parasites. To obtain stable strains of the parasites for long term experiments, a rapid and definitive method of cloning was developed using micropipets and a micromanipulator. Homogeneous parasite clones prepared by this technique were characterized and compared… (More)


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