Plasmodium falciparum: chondroitin sulfate A is the major receptor for adhesion of parasitized erythrocytes in the placenta.

@article{Fried2006PlasmodiumFC,
  title={Plasmodium falciparum: chondroitin sulfate A is the major receptor for adhesion of parasitized erythrocytes in the placenta.},
  author={Michal W Fried and Gonzalo J. Domingo and Channe D Gowda and Theonest K. Mutabingwa and Patrick E Duffy},
  journal={Experimental parasitology},
  year={2006},
  volume={113 1},
  pages={36-42}
}
Plasmodium falciparum parasites that sequester in the placenta bind to the molecule chondroitin sulfate A (CSA). Women become resistant to malaria during pregnancy as they acquire antibodies that inhibit parasite adhesion to CSA, suggesting that a vaccine against placental malaria is feasible. Hyaluronic acid (HA) and non-immune IgG have also been proposed as receptors for P. falciparum adhesion in the placenta, but evidence for their roles is inconclusive. In this study, CSA, HA, and IgG were… CONTINUE READING

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