• Corpus ID: 46535123

Plasmodium chabaudi p 68 serine protease activity required for merozoite entry into mouse erythrocytes ( erythrocye invasion / malaria pasites / Plasmodiumfalciwrum )

@inproceedings{Breton2004PlasmodiumCP,
  title={Plasmodium chabaudi p 68 serine protease activity required for merozoite entry into mouse erythrocytes ( erythrocye invasion / malaria pasites / Plasmodiumfalciwrum )},
  author={Catherine Braun Breton and Thierry Blisnick and H Jouin and Jean Christophe Barale and Thierry and RABILLOUDf and Gordon Langsley and Luis Pereira da Silva},
  year={2004}
}
To define the role of malaria parasite enzymes during the process of erythrocyte invasion, we have developed an in vitro serum-free invasion assay of mouse erythrocytes by purified Plasmodium chabaudi merozoites. The sensitivity of a merozoite-specific serine protease (p68) to various inhibitors and the effect of these inhibitors on invasion indicate a crucial role for p68. The substrate specificity of the purified enzyme has been partially defined using fluorogenic peptides. Consistent with… 

Figures and Tables from this paper

References

Cellular and Molecular Biology ofNormal andAbnormal Erythroid Membranes
  • J. Clin. Invest
  • 1983