Plasmodium chabaudi: association of reversal of chloroquine resistance with increased accumulation of chloroquine in resistant parasites.

  title={Plasmodium chabaudi: association of reversal of chloroquine resistance with increased accumulation of chloroquine in resistant parasites.},
  author={Atsushi Miki and Kazuyuki Tanabe and Takao Nakayama and C Kiryon and Kumiko Ohsawa},
  journal={Experimental parasitology},
  volume={74 2},


Imipramine reversed CQ resistance, within 3 days, in all patients (cure rate of 100%), with mild to moderate side effects.

In vitro chloroquine resistance modulation study on fresh isolates of Brazilian Plasmodium falciparum: intrinsic antimalarial activity of phenothiazine drugs.

Phenothiazine drugs - fluphenazine, chlorpromazine, methotrimeprazine and trifluoperazine - were evaluated as modulating agents against Brazilian chloroquine-resistant fresh isolates of Plasmodium

Quinoline-resistance reversing agents for the malaria parasite Plasmodium falciparum.

  • D. V. van SchalkwykT. Egan
  • Medicine, Biology
    Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy
  • 2006

Citalopram enhances the activity of chloroquine in resistant plasmodium in vitro and in vivo.

The results of this study suggest that citalopram may have potential as a chemosensitizer in Plasmodium infections on the basis of the low toxicity of cITALopram at concentrations potentiating chloroquine activity both in vitro and in vivo.

Reversal of chloroquine resistance in falciparum malaria by some calcium channel inhibitors and optical isomers is independent of calcium channel blockade.

The data strongly indicate that the mechanism of reversal of CQ resistance of falciparum malaria in vitro is independent of the calcium channel.

In vitro drug interaction between amantadine and classical antimalarial drugs in Plasmodium falciparum infections.

  • S. G. EvansI. Havlik
  • Medicine, Biology
    Transactions of the Royal Society of Tropical Medicine and Hygiene
  • 1994

A Whole Cell Pathway Screen Reveals Seven Novel Chemosensitizers to Combat Chloroquine Resistant Malaria

A simple and direct means to rapidly screen for resistance-conferring mutations in chloroquine using a fluorescent-tagged CQ molecule and two which showed greater potency than the classical chemosensitizers verapamil and desipramine are proposed.

A chloroquine-like molecule designed to reverse resistance in Plasmodium falciparum.

A preliminary study in mice demonstrated oral efficacy against P. chabaudi and the absence of obvious toxicity, and the RCQ approach appears to be feasible.



Ultrastructural changes associated with reversal of chloroquine resistance by verapamil in Plasmodium chabaudi

Results suggest that swelling of the food vacuoles is an initial event associated with reversal of CQ-resistance by verapamil, and this phenomenon appears to be very similar to those observed in C Q-sensitive P. chabaudi in mice injected with CQ alone or CQ plus verAPamil.

Efflux of chloroquine from Plasmodium falciparum: mechanism of chloroquine resistance.

Verapamil and two other calcium channel blockers, as well as vinblastine and daunomycin, each slowed the release and increased the accumulation of chloroquine by resistant (but not susceptible) Plasmodium falciparum.

Chloroquine resistance not linked to mdr-like genes in a Plasmodium falciparum cross

A genetic cross between CQR and chloroquine-susceptible (CQS) clones of P. falciparum indicated that the genetic locus governingchloroquine efflux and resistance is independent of the known mdr-like genes.

Reversal of chloroquine resistance in malaria parasite Plasmodium falciparum by desipramine.

Desipramine was found to be one of the most effective compounds yet described for the reversal of chloroquine resistance both in vitro and in vivo.

Genetics of chloroquine resistance in malaria parasites

It is shown that resistance to the antifolate drug pyrimethamine arises by mutation and that the genetic factors involved can undergo recombination with other markers in crosses between resistant and sensitive parasite lines.

Several alleles of the multidrug-resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum

It is concluded that a mutated pfmdr1 gene is one of at least two mutated genes required for CQR, and the CQS/CQR status of a further 34 out of 36 isolates is correctly predicted.