Plasmodium chabaudi: association of reversal of chloroquine resistance with increased accumulation of chloroquine in resistant parasites.

@article{Miki1992PlasmodiumCA,
  title={Plasmodium chabaudi: association of reversal of chloroquine resistance with increased accumulation of chloroquine in resistant parasites.},
  author={Atsushi Miki and Kazuyuki Tanabe and Takao Nakayama and C Kiryon and Kumiko Ohsawa},
  journal={Experimental parasitology},
  year={1992},
  volume={74 2},
  pages={
          134-42
        }
}
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24 Citations

IMIPRAMINE INDUCED COMPLETE REVERSAL OF CHLOROQUINE RESISTANCE IN PLASMODIUM FALCIPARUM INFECTIONS IN SUDAN

Imipramine reversed CQ resistance, within 3 days, in all patients (cure rate of 100%), with mild to moderate side effects.

High-level chloroquine resistance of Plasmodium berghei is associated with multiple drug resistance and loss of reversal by calcium antagonists.

In vitro chloroquine resistance modulation study on fresh isolates of Brazilian Plasmodium falciparum: intrinsic antimalarial activity of phenothiazine drugs.

Phenothiazine drugs - fluphenazine, chlorpromazine, methotrimeprazine and trifluoperazine - were evaluated as modulating agents against Brazilian chloroquine-resistant fresh isolates of Plasmodium…

Quinoline-resistance reversing agents for the malaria parasite Plasmodium falciparum.

  • D. V. van SchalkwykT. Egan
  • Medicine, Biology
    Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy
  • 2006

Citalopram enhances the activity of chloroquine in resistant plasmodium in vitro and in vivo.

The results of this study suggest that citalopram may have potential as a chemosensitizer in Plasmodium infections on the basis of the low toxicity of cITALopram at concentrations potentiating chloroquine activity both in vitro and in vivo.

Interaction between chloroquine and diverse pharmacological agents in chloroquine resistant Plasmodium yoelii nigeriensis.

Reversal of chloroquine resistance in falciparum malaria by some calcium channel inhibitors and optical isomers is independent of calcium channel blockade.

The data strongly indicate that the mechanism of reversal of CQ resistance of falciparum malaria in vitro is independent of the calcium channel.

In vitro drug interaction between amantadine and classical antimalarial drugs in Plasmodium falciparum infections.

  • S. G. EvansI. Havlik
  • Medicine, Biology
    Transactions of the Royal Society of Tropical Medicine and Hygiene
  • 1994

A Whole Cell Pathway Screen Reveals Seven Novel Chemosensitizers to Combat Chloroquine Resistant Malaria

A simple and direct means to rapidly screen for resistance-conferring mutations in chloroquine using a fluorescent-tagged CQ molecule and two which showed greater potency than the classical chemosensitizers verapamil and desipramine are proposed.

A chloroquine-like molecule designed to reverse resistance in Plasmodium falciparum.

A preliminary study in mice demonstrated oral efficacy against P. chabaudi and the absence of obvious toxicity, and the RCQ approach appears to be feasible.

References

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Ultrastructural changes associated with reversal of chloroquine resistance by verapamil in Plasmodium chabaudi

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Several alleles of the multidrug-resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum

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