Plasmodium berghei sporozoites acquire virulence and immunogenicity during mosquito hemocoel transit.

@article{Sato2014PlasmodiumBS,
  title={Plasmodium berghei sporozoites acquire virulence and immunogenicity during mosquito hemocoel transit.},
  author={Yuko Sato and Georgina Nuri Montagna and Kai Matuschewski},
  journal={Infection and immunity},
  year={2014},
  volume={82 3},
  pages={
          1164-72
        }
}
Malaria is a vector-borne disease caused by the single-cell eukaryote Plasmodium. The infectious parasite forms are sporozoites, which originate from midgut-associated oocysts, where they eventually egress and reach the mosquito hemocoel. Sporozoites actively colonize the salivary glands in order to be transmitted to the mammalian host. Whether residence in the salivary glands provides distinct and vital cues for the development of infectivity remains unsolved. In this study, we systematically… CONTINUE READING

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