Plasmodium berghei: analysis of the gamma-glutamylcysteine synthetase gene in drug-resistant lines.

@article{PrezRosado2002PlasmodiumBA,
  title={Plasmodium berghei: analysis of the gamma-glutamylcysteine synthetase gene in drug-resistant lines.},
  author={Jos{\'e} P{\'e}rez-Rosado and Gary W. Gervais and Iv{\'a}n Ferrer-Rodr{\'i}guez and Wallace Peters and Adelfa E. Serrano},
  journal={Experimental parasitology},
  year={2002},
  volume={101 4},
  pages={
          175-82
        }
}
The rapid emergence of multidrug-resistant Plasmodium falciparum is a worldwide concern. Despite the magnitude of the problem, the mechanisms involved in this phenomenon are not well understood. One current proposal suggests that toxic heme molecules are degraded by glutathione (GSH), and that anti-malarial drugs, such as chloroquine (CQ), inhibit this degradation, thus implicating GSH in drug resistance. Furthermore, in some strains of Plasmodium berghei and P. falciparum, chloroquine… CONTINUE READING

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