Plasmodium UIS3 sequesters host LC3 to avoid elimination by autophagy in hepatocytes

  title={Plasmodium UIS3 sequesters host LC3 to avoid elimination by autophagy in hepatocytes},
  author={Eliana Real and L{\'e}nia Rodrigues and Ghislain G. Cabal and Francisco Javier Enguita and Liliana Mancio-Silva and Jo{\~a}o Mello-Vieira and Wandy L. Beatty and Iset Medina Vera and Vanessa Zuzarte-Lu{\'i}s and Tiago N Figueira and Gunnar R Mair and Maria M Mota},
  booktitle={Nature Microbiology},
The causative agent of malaria, Plasmodium, replicates inside a membrane-bound parasitophorous vacuole (PV), which shields this intracellular parasite from the cytosol of the host cell 1 . One common threat for intracellular pathogens is the homeostatic process of autophagy, through which cells capture unwanted intracellular material for lysosomal degradation 2 . During the liver stage of a malaria infection, Plasmodium parasites are targeted by the autophagy machinery of the host cell, and the… CONTINUE READING


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