Plasmodium 18S rRNA of intravenously administered sporozoites does not persist in peripheral blood

@inproceedings{Murphy2018Plasmodium1R,
  title={Plasmodium 18S rRNA of intravenously administered sporozoites does not persist in peripheral blood},
  author={Sean C Murphy and Andrew S Ishizuka and Zachary P. Billman and Tayla M. Olsen and Annette M. Seilie and Ming Chang and Nahum T Smith and Vorada Chuenchob and Sumana Chakravarty and Betty Kim Lee Sim and Stefan H Kappe and Stephen L. Hoffman and Robert A Seder},
  booktitle={Malaria Journal},
  year={2018}
}
BackgroundPlasmodium 18S rRNA is a biomarker used to monitor blood-stage infections in malaria clinical trials. Plasmodium sporozoites also express this biomarker, and there is conflicting evidence about how long sporozoite-derived 18S rRNA persists in peripheral blood. If present in blood for an extended timeframe, sporozoite-derived 18S rRNA could complicate use as a blood-stage biomarker.MethodsBlood samples from Plasmodium yoelii infected mice were tested for Plasmodium 18S rRNA and their… CONTINUE READING
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