Plasminogen regulates stromal cell-derived factor-1/CXCR4-mediated hematopoietic stem cell mobilization by activation of matrix metalloproteinase-9.

@article{Gong2011PlasminogenRS,
  title={Plasminogen regulates stromal cell-derived factor-1/CXCR4-mediated hematopoietic stem cell mobilization by activation of matrix metalloproteinase-9.},
  author={Yanqing Gong and Yi Hua Fan and Jane Hoover-Plow},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2011},
  volume={31 9},
  pages={
          2035-43
        }
}
OBJECTIVE Granulocyte colony-stimulating factor (G-CSF) is a widespread therapeutic agent for stimulation of hematopoietic progenitor and stem cell (HPSC) mobilization from bone marrow (BM). Plasminogen (Plg) has been shown to be critical for HPSC mobilization. Here, we investigated the role of Plg in G-CSF-induced HPSC mobilization and the underlying mechanism. METHODS AND RESULTS By using gene-targeted mice, our data show that Plg is required for G-CSF-induced HPSC egress to sinusoidal… CONTINUE READING

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