Plasminogen-mediated activation and release of hepatocyte growth factor from extracellular matrix.

@article{Matsuoka2006PlasminogenmediatedAA,
  title={Plasminogen-mediated activation and release of hepatocyte growth factor from extracellular matrix.},
  author={Hiroto Matsuoka and Thomas H. Sisson and Teruaki Nishiuma and Richard H. Simon},
  journal={American journal of respiratory cell and molecular biology},
  year={2006},
  volume={35 6},
  pages={
          705-13
        }
}
Interventions that enhance plasminogen activation within the lung consistently limit the fibrosis that follows alveolar injury. However, this protective effect cannot be attributed solely to accelerated clearance of fibrin that forms as a provisional matrix after lung injury. To explore other mechanisms, we considered interactions between the plasminogen activation system and hepatocyte growth factor (HGF). HGF is known to have antifibrotic activity, but to do so, it must be both released from… CONTINUE READING

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