Plasminogen kringle 5 inhibits alkali-burn-induced corneal neovascularization.

  title={Plasminogen kringle 5 inhibits alkali-burn-induced corneal neovascularization.},
  author={Zhihong Zhang and Jian-xing Ma and Guoquan Gao and Chaoyang Li and Lihui Luo and Mei Zhang and Wenzhao Yang and Aihua Jiang and Wenhui Kuang and Liying Xu and Jiaqi Chen and Zu-guo Liu},
  journal={Investigative ophthalmology & visual science},
  volume={46 11},
PURPOSE Plasminogen kringle 5 (K5) is a potent angiogenic inhibitor. The purpose of the present study was to evaluate the therapeutic effect of K5 on alkali-burn-induced corneal neovascularization (NV) and to investigate its mechanism of action. METHODS Corneal NV was induced in rabbits by NaOH. The rabbits received eye drops containing K5 or vehicle alone, four times per day. Corneal NV and inflammation were monitored every other day with a slit lamp microscope, and the length of the vessels… CONTINUE READING


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