Plasminogen inhibits TNF-induced apoptosis in monocytes

  title={Plasminogen inhibits TNF-induced apoptosis in monocytes},
  author={Jennifer W. Mitchell and Nagyung Baik and Francis J. Castellino and Lindsey A. Miles},
Monocytes are major mediators of inflammation, and apoptosis provides a mechanism for regulating the inflammatory response by eliminating activated macrophages. Furthermore, as a consequence of apoptosis, plasminogen binding is markedly increased on monocytoid cells. Therefore, we investigated the ability of plasminogen to modulate monocyte apoptosis. Apoptosis of monocytoid cells (human monocytes and U937 cells) was induced with either TNF or cycloheximide. When apoptosis was induced in the… CONTINUE READING