Plasminogen enhances virulence of group A streptococci by streptokinase-dependent and streptokinase-independent mechanisms.

@article{Khil2003PlasminogenEV,
  title={Plasminogen enhances virulence of group A streptococci by streptokinase-dependent and streptokinase-independent mechanisms.},
  author={Jinmo Khil and Michael Y Im and A. Heath and Ulrika Ringdahl and Lakshmi V Mundada and N Cary Engleberg and William P. Fay},
  journal={The Journal of infectious diseases},
  year={2003},
  volume={188 4},
  pages={497-505}
}
Interactions between host plasminogen (Plg) and streptokinase (SK) secreted by group A streptococci (GAS) have been hypothesized to promote bacterial invasion of tissues. The virulence of GAS strain UMAA2616, after being subcutaneously inoculated into mice, was studied. Skin lesions and mortality were observed after inoculation of 7x106 cfu. Coadministration of human Plg with UMAA2616 markedly increased virulence. SK-deficient UMAA2616 (UMAA2616-SK(-)) was generated. Mean skin-lesion area and… CONTINUE READING

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