Plasminogen and its receptors as regulators of cardiovascular inflammatory responses.

  title={Plasminogen and its receptors as regulators of cardiovascular inflammatory responses.},
  author={Riku Das and Elzbieta Pluskota and Edward F Plow},
  journal={Trends in cardiovascular medicine},
  volume={20 4},
In addition to its role in fibrinolysis, plasminogen (Plg) influences inflammatory cell migration and thereby plays a prominent role in cardiovascular pathology. The contribution of Plg to inflammatory cell recruitment depends on its tethering to the surface of responding cells. Plasminogen receptors (Plg-Rs) are heterogeneous and can be classified as tailless, lacking cytoplasmic tails, or tailed (having cytoplasmic tails). In vivo observations implicate several tailless Plg-Rs in inflammatory… CONTINUE READING


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