Plasminogen activators in human prostate cancer cell lines and tumors: correlation with the aggressive phenotype.

@article{Gaylis1989PlasminogenAI,
  title={Plasminogen activators in human prostate cancer cell lines and tumors: correlation with the aggressive phenotype.},
  author={Franklin D. Gaylis and H N Keer and Megan J. Wilson and Hau C. Kwaan and Akhouri A. Sinha and James M. Kozlowski},
  journal={The Journal of urology},
  year={1989},
  volume={142 1},
  pages={193-8}
}
The levels of several tumor associated proteases, including plasminogen activators (PA), are elevated in many malignant tumors compared to their benign tumor counterparts. Extracellular matrix degradation mediated by PA may facilitate tumor cell invasion and metastasis. To assess whether PA content correlates with the aggressive phenotype in prostate cancer, we studied these activators in the PC-3 human prostate cell line and PC-3CALN, an aggressive in vivo derived variant cell line. Enzymatic… CONTINUE READING

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