Plasminogen activator inhibitor type I contributes to protective immunity during experimental Gram-negative sepsis (melioidosis).

@article{Kager2011PlasminogenAI,
  title={Plasminogen activator inhibitor type I contributes to protective immunity during experimental Gram-negative sepsis (melioidosis).},
  author={Liesbeth Martine Kager and W Joost Wiersinga and Joris J. T. H. Roelofs and Joost C M Meijers and Marcel Levi and Cornelis van't Veer and Tom van der Poll},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2011},
  volume={9 10},
  pages={2020-8}
}
BACKGROUND Melioidosis is a frequent cause of sepsis in Southeast Asia caused by the Gram-negative bacterium Burkholderia pseudomallei. Patients with melioidosis have elevated circulating levels of plasminogen activator inhibitor type 1 (PAI-1), an important regulator of inflammation and fibrinolysis. OBJECTIVES In this study, we aimed to investigate the role of PAI-1 during melioidosis. METHODS Wild-type (WT) and PAI-1-deficient (PAI-1-/1(-/-) ) mice were intranasally infected with B… CONTINUE READING

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