Plasminogen activator inhibitor type-1: its structure, biological activity and role in tumorigenesis (Review).

@article{cHorostoWskAWynIMko2004PlasminogenAI,
  title={Plasminogen activator inhibitor type-1: its structure, biological activity and role in tumorigenesis (Review).},
  author={joAnnA cHorostoWskA-WynIMko and Ewa Skrzypczak-Jankun and Jerzy Jankun},
  journal={International journal of molecular medicine},
  year={2004},
  volume={13 6},
  pages={
          759-66
        }
}
Plasminogen activator inhibitor type-1 (PAI-1), is a unique member of serpin superfamily, the primary regulator of plasminogen activation and therefore essential factor regulating physiological thrombotic/fibrinolytic balance in vivo. Via interactions with integrins and extracellular matrix components it orchestrates also cell adhesion and migration. Therefore, PAI-1 is considered one of the key regulators of tumor invasion and metastasis, as well as cancer-related angiogenesis. This review… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 32 CITATIONS

Circulating plasminogen activator inhibitor-1 activity: a biomarker for resectable non-small cell lung cancer?

George P Sotiropoulos, Marianna Kotopouli, +7 authors Maria Dalamaga
  • Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • 2019
VIEW 4 EXCERPTS
CITES RESULTS & BACKGROUND
HIGHLY INFLUENCED

Structural Principles in the Development of Cyclic Peptidic Enzyme Inhibitors

  • International journal of biological sciences
  • 2017
VIEW 1 EXCERPT
CITES BACKGROUND